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1-Phenazinol,6-methoxy-, 5,10-dioxide

Names

[ CAS No. ]:
13925-12-7

[ Name ]:
1-Phenazinol,6-methoxy-, 5,10-dioxide

[Synonym ]:
Myxin
6-Methoxy-1-phenazinol 5,10-dioxide
1-Hydroxy-6-methoxyphenazine 5,10-dioxide
1-hydroxy-6-methoxyphenazine N5,N10-dioxide
3C Antibiotic
1-Phenazinol,6-methoxy-,5,10-dioxide
6-methoxy-5,10-dioxy-phenazin-1-ol
1-Methoxy-6-hydroxyphenazin-5,10-dioxid

Biological Activity

[Description]:

Myxin is a di-N-oxide phenazine produced by Lysobacter antibioticus OH13. Myxin is toxic to many microorganisms and tumor cells[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. Liu J, et al. Monooxygenase LaPhzX is Involved in Self-Resistance Mechanisms during the Biosynthesis of N-Oxide Phenazine Myxin. J Agric Food Chem. 2021;69(45):13524-13532.

Chemical & Physical Properties

[ Density]:
1.53g/cm3

[ Boiling Point ]:
538.8ºC at 760mmHg

[ Molecular Formula ]:
C13H10N2O4

[ Molecular Weight ]:
258.23000

[ Flash Point ]:
279.7ºC

[ Exact Mass ]:
258.06400

[ PSA ]:
80.38000

[ LogP ]:
2.56420

[ Vapour Pressure ]:
1.93E-12mmHg at 25°C

[ Index of Refraction ]:
1.73

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SG1660000
CHEMICAL NAME :
1-Phenazinol, 6-methoxy-, 5,10-dioxide
CAS REGISTRY NUMBER :
13925-12-7
BEILSTEIN REFERENCE NO. :
0622031
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C13-H10-N2-O4
MOLECULAR WEIGHT :
258.25
WISWESSER LINE NOTATION :
T C666 BN INJ BO DQ IO KO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
133 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Protozoa - Euglena gracilis
DOSE/DURATION :
10 mg/L
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 27,586,1971

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Precursor & DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%


Related Compounds