H2L5186303

Names

[ Name ]:
H2L5186303

[Synonym ]:
2-Butenoic acid, 4,4'-[1,3-phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-, (2Z,2'Z)-
(2Z,2'Z)-4,4'-[1,3-Phenylenebis(oxy-4,1-phenyleneimino)]bis(4-oxo-2-butenoic acid)

Biological Activity

[Description]:

H2L5186303 is a potent and selective LPA2 receptor (lysophosphatidic acid 2 receptor) antagonist with an IC50 of 9 nM[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> GPCR/G Protein >> LPL Receptor

[Target]

LPA2 Receptor:9 nM (IC50)

[References]

[1]. Fells JI, et al. Structure-based drug design identifies novel LPA3 antagonists. Bioorg Med Chem. 2009 Nov 1;17(21):7457-64.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
801.0±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₆H₂₀N₂O₈

[ Molecular Weight ]:
488.446

[ Flash Point ]:
438.2±34.3 °C

[ Exact Mass ]:
488.121979

[ LogP ]:
4.46

[ Vapour Pressure ]:
0.0±3.0 mmHg at 25°C

[ Index of Refraction ]:
1.688

[ Storage condition ]:
2-8°C

Safety Information

[ RIDADR ]:
NONH for all modes of transport