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Propargyl-PEG5-NHS ester

Names

[ CAS No. ]:
1393330-40-9

[ Name ]:
Propargyl-PEG5-NHS ester

[Synonym ]:
1-(4,7,10,13,16-Pentaoxanonadec-18-ynoyloxy)-2,5-pyrrolidinedione
2,5-Pyrrolidinedione, 1-[(1-oxo-4,7,10,13,16-pentaoxanonadec-18-yn-1-yl)oxy]-
MFCD22574798

Biological Activity

[Description]:

Propargyl-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[References]

[1]. Zhenjun Diwu, et al. Polyfluoreno[4,5-cde]oxepine Conjugates and Their Use in Methods of Analyte Detection. US20170275418A1.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
497.6±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H27NO9

[ Molecular Weight ]:
401.408

[ Flash Point ]:
254.8±31.5 °C

[ Exact Mass ]:
401.168579

[ LogP ]:
-2.68

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.502

[ Storage condition ]:
2-8°C

Related Compounds