RY796 R-form

Names

[ Name ]:
RY796 R-form

Biological Activity

[Description]:

RY796 is a potent and selective voltage-gated potassium (KV2) channel inhibitor with IC50s of 0.25 μM and 0.09 μM for KV2.1 and KV2.2. RY796 has analgesic activity[1].

[Target]

IC50: 0.25 μM (KV2.1) and 0.09 μM (KV2.2)[1]

[References]

[1]. Herrington J, et al. Identification of novel and selective Kv2 channel inhibitors. Mol Pharmacol. 2011 Dec;80(6):959-64.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₇N₃O₂

[ Molecular Weight ]:
353.46

Related Compounds

EMD638683 (R-Form)
MGV354 R-form
GW-766994 R-form
GDC-0927 R-form
Bay 65-1942 (R form)
H-D-Asp-OH
N-(4-(1H-tetrazol-1-yl)phenyl)-2-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-oxoimidazolidin-1-yl)acetamide
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-(2-(4-(2-fluorophenyl)piperazin-1-yl)-2-oxoethyl)-7-methyl-5-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3(2H)-one
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
2-{[(4-Methylphenyl)methyl](prop-2-yn-1-yl)amino}-1-(4-phenylmethanesulfonylpiperazin-1-yl)ethan-1-one
(4-(3-(3-fluorophenyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)piperazin-1-yl)(4-methoxyphenyl)methanone
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide