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Nomega-Allyl-L-arginine hydrochloride

Names

[ CAS No. ]:
139461-37-3

[ Name ]:
Nomega-Allyl-L-arginine hydrochloride

[Synonym ]:
L-Ornithine,N5-(imino(2-propenylamino)methyl)
N(G)-Allylarginine
NG-allyl-L-arginine
Nw-allyl-L-arginine
ARV

Biological Activity

[Description]:

Nω-allyl-L-arginine is a competitive and reversible inhibitor of bovine brain nitric oxide synthase (nNOS). Nω-allyl-L-arginine can inactivate nNOS in a time-dependent manner. Nω-allyl-L-arginine also is a substrate, producing L-arginine, acrolein, and H2O[1][2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> NO Synthase
Research Areas >> Neurological Disease

[Target]

nitric oxide synthase (nNOS)[1]


[References]

[1]. Zhang HQ, et, al. Mechanism of Inactivation of Neuronal Nitric Oxide Synthase by Nω-Allyl-l-Arginine. J. Am. Chem. Soc. 1997, 119, 45, 10888-10902.

[2]. Hah JM, et, al. Deuterium isotope effects and product studies for the oxidation of N(omega)-allyl-L-arginine and N(omega)-allyl-N(omega)-hydroxy-L-arginine by neuronal nitric oxide synthase. Bioorg Med Chem. 2000 Aug;8(8):1931-6.

Chemical & Physical Properties

[ Density]:
1.23g/cm3

[ Boiling Point ]:
394.4ºC at 760mmHg

[ Molecular Formula ]:
C9H18N4O2

[ Molecular Weight ]:
214.26500

[ Flash Point ]:
192.3ºC

[ Exact Mass ]:
214.14300

[ PSA ]:
111.23000

[ LogP ]:
1.06030

[ Vapour Pressure ]:
2.54E-07mmHg at 25°C

[ Index of Refraction ]:
1.549

Precursor & DownStream

Precursor

DownStream

Related Compounds