depudecin

Names

[ Name ]:
depudecin

[Synonym ]:
4,5:8,9-Dianhydro-1,2,6,7,11-pentadeoxy-D-threo-D-ido-undeca-1,6-dienitol
(−)-Depudecin
(2R,3S,4S,5E,7S,8S,9R)-2,9-dihydroxy-3,4,7,8-diepoxy-undeca-5,10-diene
4,5:8,9-dianhydro-1,2,6,7,11-pentadeoxy-D-threo-D-ido-undeco-1,6-dienitol
* (1R)-[(2S,3S)-3-[(E)-2-[(2S,3S)-3-[(1R)-Hydroxyethyl]oxiran-2-yl]vinyl]oxiran-2-yl]-2-propen-1-ol
(1R)-1-[(2S,3S)-3-[2-[(2S,3S)-3-[(1R)-1-hydroxyethyl]oxiran-2-yl]ethenyl]oxiran-2-yl]prop-2-en-1-ol

Biological Activity

[Description]:

Depudecin ((-)-Depudecin) is a histone deacetylase (HDAC) inhibitor. Depudecin can be isolated from the fungus Alternaria brassicicola[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC

Research Areas >> Neurological Disease

Signaling Pathways >> Epigenetics >> HDAC

[In Vitro]

Depudecin (48 h) 可以诱导由 ras 和 src 癌基因双重转化的 NIH3T3 细胞的扁平表型[1]。

[References]

[1]. Hannah T Reynolds, et al. Differential Retention of Gene Functions in a Secondary Metabolite Cluster. Mol Biol Evol. 2017 Aug 1;34(8):2002-2015.

[2]. M Matsumoto, et al. Depudecin: a novel compound inducing the flat phenotype of NIH3T3 cells doubly transformed by ras- and src-oncogene, produced by Alternaria brassicicola. J Antibiot (Tokyo). 1992 Jun;45(6):879-85.

Chemical & Physical Properties

[ Density]:
1.415g/cm3

[ Boiling Point ]:
369.4ºC at 760mmHg

[ Molecular Formula ]:
C₁₁H₁₆O₄

[ Molecular Weight ]:
212.24200

[ Flash Point ]:
177.2ºC

[ Exact Mass ]:
212.10500

[ PSA ]:
65.52000

[ LogP ]:
0.00510

[ Vapour Pressure ]:
5.83E-07mmHg at 25°C

[ Index of Refraction ]:
1.706

MSDS

Click to get detail MSDS

Safety Information

[ Safety Phrases ]:
S22