6-(6-(4-hydroxypiperidinyl)hexyloxy)-3-methylflavone HCl

Names

[ Name ]:
6-(6-(4-hydroxypiperidinyl)hexyloxy)-3-methylflavone HCl

[Synonym ]:
6-[6-(4-Hydroxypiperidinyl)hexoxy]-3-methyl-2-phenyl-4H-1-benzopyran-4-one hydrochloride
6-(6-(4-Hydroxypiperidinyl)hexyloxy)-3-methylflavone HCl
4H-1-Benzopyran-4-one,6-((6-(4-hydroxy-1-piperidinyl)hexyl)oxy)-3-methyl-2-phenyl-,hydrochloride
6-(6-(4-hydroxypiperidinyl)hexyloxy)-3-methylflavone hydrochloride

Biological Activity

[Description]:

Sigma-LIGAND-1 hydrochloride is a selective sigma receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. Sigma-LIGAND-1 hydrochloride has a Ki of 4000 nM at the dopamine D2 receptor[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Sigma Receptor

[Target]

IC50: 16 nM (DTG site of sigma receptor), 19 nM (PPP site of sigma receptor)[1] Ki: 4000 nM (Dopamine D2 receptor)[1]

[In Vivo]

Administration of Sigma-LIGAND-1 hydrochloride reverseS amphetamine-induced hyperlocomotion in mice, a behavioral model sensitive to antipsychotic compounds. Sigma-LIGAND-1 hydrochloride and its structural analogues have the potential antipsychotic activity[1].

[References]

[1]. Erickson RH, et al. (Aminoalkoxy)chromones. Selective sigma receptor ligands. J Med Chem. 1992 May 1;35(9):1526-35.

Chemical & Physical Properties

[ Boiling Point ]:
615.5ºC at 760 mmHg

[ Molecular Formula ]:
C₂₇H₃₄ClNO₄

[ Molecular Weight ]:
472.01600

[ Flash Point ]:
326.1ºC

[ Exact Mass ]:
471.21800

[ PSA ]:
62.91000

[ LogP ]:
5.90420

[ Vapour Pressure ]:
5.23E-16mmHg at 25°C