KNI-102

Names

[ CAS No. ]:
139694-65-8

[ Name ]:
KNI-102

[Synonym ]:
Rpi 312
(S)-N-tert-butyl-3-[(2S,3S)-2-hydroxy-3-[(S)-2-benzyloxycarbonylaminosuccinamyl]amino-4-phenylbutanoyl]pyrrolidine-2-carboxamide
AHPBA 1a
Z-Asn-apns-pro-NH-t-but
Cbz-Asn-Apns-Pro-NH-tBu
Kni-102

Biological Activity

[Description]:

KNI-102 is a potent anti-HIV agent with an IC50 value of 100 nM for HIV protease[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection

[References]

[1]. Mimoto T, et al. KNI-102, a novel tripeptide HIV protease inhibitor containing allophenylnorstatine as a transition-state mimic. Chem Pharm Bull (Tokyo). 1991 Nov;39(11):3088-90.  

Chemical & Physical Properties

[ Density]:
1.262g/cm3

[ Boiling Point ]:
964.2ºC at 760mmHg

[ Molecular Formula ]:
C31H41N5O7

[ Molecular Weight ]:
595.68700

[ Flash Point ]:
536.9ºC

[ Exact Mass ]:
595.30100

[ PSA ]:
191.62000

[ LogP ]:
4.12350

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.583

Precursor & DownStream

Precursor

DownStream

Related Compounds