Thiol-PEG2-t-butyl ester

Names

[ Name ]:
Thiol-PEG2-t-butyl ester

[Synonym ]:
Propanoic acid, 3-[2-(2-mercaptoethoxy)ethoxy]-, 1,1-dimethylethyl ester
MFCD22574781
2-Methyl-2-propanyl 3-[2-(2-sulfanylethoxy)ethoxy]propanoate

Biological Activity

[Description]:

Thiol-PEG2-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
330.6±27.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₁H₂₂O₄S

[ Molecular Weight ]:
250.355

[ Flash Point ]:
200.0±11.6 °C

[ Exact Mass ]:
250.123886

[ LogP ]:
1.75

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.462

Thiol-PEG2-t-butyl ester

Names

Biological Activity

Chemical & Physical Properties

Related Compounds