JAK-IN-3

Names

[ CAS No. ]:
1400876-94-9

[ Name ]:
JAK-IN-3

Biological Activity

[Description]:

JAK-IN-3 (compound 22) is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively[1].

[Related Catalog]:

Signaling Pathways >> JAK/STAT Signaling >> JAK
Signaling Pathways >> Epigenetics >> JAK
Signaling Pathways >> Stem Cell/Wnt >> JAK
Research Areas >> Others

[Target]

JAK3:3 nM (IC50)

JAK1:5 nM (IC50)

Tyk2:34 nM (IC50)

JAK2:70 nM (IC50)


[References]

[1]. Spergel SH, et al. Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis. ACS Med Chem Lett. 2019 Feb 13;10(3):306-311.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H20N4O3

[ Molecular Weight ]:
340.38

Related Compounds