ATIC-IN-1
Names
[ CAS No. ]:
1402453-15-9
[ Name ]:
ATIC-IN-1
Biological Activity
[Description]:
ATIC-IN-1(compound 14) is an inhibitor targeting to Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) dimerization with a Ki value of 685 nM. ATIC dimerization is crucial for its aminoimidazole carboxamide ribonucleotide (AICAR) transformylase activity. ATIC-IN-1 exhibits anti-tumor activity via reduction in cell numbers and cell division rates[1].
[Related Catalog]:
[Target]
Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC)[1]
[In Vitro]
ATIC-IN-1(10 μM, 50 μM)是一种特异性抑制剂,在 1 mg/mL 和 10 mg/mL BSA 存在或不存在时,表现出非特异性聚集机制[1]。 ATIC-IN-1(100-500 μM;48 h)抑制 MCF-7 细胞的增殖[1]。 ATIC-IN-1(250 μM;24-72 小时)导致分裂减少而不是导致细胞死亡增加[1]。 Cell Viability Assay[1] Cell Line: MCF-7 cells Concentration: 100 μM, 250 μM, 500 μM Incubation Time: 0 h, 24 h, 48 h, and 72 h Result: Reduced the division rate to inhibit MCF-7 proliferation at 250 μM.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C21H33N7O5
[ Molecular Weight ]:
463.53062