N-Boc-PEG5-alcohol

Names

[ Name ]:
N-Boc-PEG5-alcohol

[Synonym ]:
2-Methyl-2-propanyl (14-hydroxy-3,6,9,12-tetraoxatetradec-1-yl)carbamate
Carbamic acid, N-(14-hydroxy-3,6,9,12-tetraoxatetradec-1-yl)-, 1,1-dimethylethyl ester

Biological Activity

[Description]:

N-Boc-PEG5-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
451.5±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₃₁NO₇

[ Molecular Weight ]:
337.409

[ Flash Point ]:
226.8±27.3 °C

[ Exact Mass ]:
337.210052

[ LogP ]:
-0.67

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.461

[ Storage condition ]:
-20°C

N-Boc-PEG5-alcohol

Names

Biological Activity

Chemical & Physical Properties

Related Compounds