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PF-719 dihydrochloride

Names

[ CAS No. ]:
1404454-02-9

[ Name ]:
PF-719 dihydrochloride

Biological Activity

[Description]:

PF-719 (PF719) is a potent, selective Pyk2 inhibitor with IC50 of 17 nM, displays 25-fold selectvity over FAK (IC50=469 nM); does not have significant inhibitory effects on recombinant MLCK2, p38, Akt1, or ROCK1, and very little inhibtion at Src family kinases (IC50>5 uM); selectively inhibits tyrosine phosphorylation of Pyk2 at 1 uM, but blocks both Pyk2 and FAK phosphorylation at 2.5 uM in A20 cells; reduces chemoattractant-induced migration of B-2 and MZ B cells.

[References]

References 1. Tse KW, et al. Cell Immunol. 2012 Jan-Feb;275(1-2):47-54. View Related Products by Target Focal Adhesion Kinase (FAK)

Chemical & Physical Properties

[ Molecular Formula ]:
C22H29Cl2F3N6O

[ Molecular Weight ]:
521.41


Related Compounds