BRD4884

Names

[ Name ]:
BRD4884

[Synonym ]:
N-(4-Amino-4'-fluoro-3-biphenylyl)tetrahydro-2H-pyran-4-carboxamide
2H-Pyran-4-carboxamide, N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)tetrahydro-
N-(4-Amino-4'-Fluoro[1,1'-Biphenyl]-3-Yl)oxane-4-Carboxamide

Biological Activity

[Description]:

BRD4884 is a potent HDAC inhibitor with IC50 values of 29 nM, 62 nM, and 1.09 µM for HDAC1, 2, and 3, respectively[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC

Research Areas >> Neurological Disease

Signaling Pathways >> Epigenetics >> HDAC

[Target]

HDAC1:29 nM (IC50)

HDAC2:62 nM (IC50)

HDAC3:1.09 μM (IC50)

[References]

[1]. Wagner FF, et al. Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers. Chem Sci. 2015 Jan 1;6(1):804-815.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
529.9±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₁₉FN₂O₂

[ Molecular Weight ]:
314.354

[ Flash Point ]:
274.3±30.1 °C

[ Exact Mass ]:
314.143066

[ LogP ]:
2.06

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.622