Hexetidine

Names

[ CAS No. ]:
141-94-6

[ Name ]:
Hexetidine

[Synonym ]:
1,3-Bis(b-ethylhexyl)-5-methyl-5-aminohexahydropyrimidine
5-Amino-1,3-di(b-ethylhexyl)hexahydro-5-methylpyrimidine
Hexetidine
Hexopyrimidine
UNII:852A84Y8LS
EINECS 205-513-5
5-Pyrimidinamine, 1,3-bis(2-ethylhexyl)hexahydro-5-methyl-
MFCD00010428
1,3-Bis(2-ethylhexyl)-5-methylhexahydro-5-pyrimidinamine
1,3-Bis(2-ethylhexyl)-5-methylhexahydropyrimidin-5-amine
1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine
1,3-Bis(2-ethylhexyl)hexahydro-5-methyl-5-pyrimidinamine
steri/sol

Biological Activity

[Description]:

Hexetidine is an anti-bacterial and anti-fungal agent commonly used in both veterinary and human medicine, is a local anesthetic.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial

Signaling Pathways >> Anti-infection >> Fungal

Research Areas >> Infection

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
388.2±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₄₅N₃

[ Molecular Weight ]:
339.602

[ Flash Point ]:
175.0±13.8 °C

[ Exact Mass ]:
339.361359

[ PSA ]:
32.50000

[ LogP ]:
7.15

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.467

[ Storage condition ]:
2-8℃

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Physicochemical characterization of hexetidine-impregnated endotracheal tube poly(vinyl chloride) and resistance to adherence of respiratory bacterial pathogens.

Pharm. Res. 19(6) , 818-24, (2002)

Ventilator-associated pneumonia is a frequent cause of mortality in intensive care patients. This study describes the physicochemical properties of hexetidine-impregnated poly(vinyl chloride) (PVC) en...

The effect of hexetidine mouthwash on the prevention of plaque and gingival inflammation: a systematic review.

Int. J. Dent. Hyg. 9(3) , 182-90, (2011)

To review the literature concerning hexetidine-containing mouthwash as a monotherapy or as an adjunct to oral hygiene in the prevention of plaque accumulation and gingival inflammation.PubMed-MEDLINE ...

The plaque inhibitory effect of a CPC mouthrinse in a 3-day plaque accumulation model - a cross-over study.

Int. J. Dent. Hyg. 8(4) , 269-75, (2010)

To test the plaque inhibitory effect of an experimental 0.07% cetylpyridinium chloride (CPC) mouthrinse in a 3-day plaque accumulation model in a cross-over design.A total of 30 subjects (non-dental s...