Filaminast

Names

[ Name ]:
Filaminast

[Synonym ]:
Filaminast (USAN/INN)
FIL
Way-pda-641
(1E)-1-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]ETHANONE O-(AMINOCARBONYL)OXIME
FILAMINAST
UNII-CDD69JC61J

Biological Activity

[Description]:

WAY-PDA 641 is a potent and preferential PDE-IV inhibitor, with an IC50 of 0.42 μM for canine trachealis PDE-IV. WAY-PDA 641 induces respiratory muscle relaxation and bronchodilation[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)

Research Areas >> Inflammation/Immunology

[References]

[1]. Heaslip RJ, et, al. Phosphodiesterase-IV inhibition, respiratory muscle relaxation and bronchodilation by WAY-PDA-641. J Pharmacol Exp Ther. 1994 Feb;268(2):888-96.

Chemical & Physical Properties

[ Density]:
1.25g/cm3

[ Boiling Point ]:
432.1ºC at 760mmHg

[ Molecular Formula ]:
C₁₅H₂₀N₂O₄

[ Molecular Weight ]:
292.33000

[ Flash Point ]:
215.1ºC

[ Exact Mass ]:
292.14200

[ PSA ]:
84.13000

[ LogP ]:
3.34970

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.566