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CDK9-IN-1

Names

[ CAS No. ]:
1415559-43-1

[ Name ]:
CDK9-IN-1

[Synonym ]:
CS-0456
CDK9 inhibitor
CDK9-IN-1

Biological Activity

[Description]:

CDK9-IN-1 is a novel, selective CDK9 inhibitor for the treatment of HIV infection, with an IC50 of 39 nM for CDK9/CycT1, extracted from reference, compound 87.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection

[Target]

CDK9/CycT1:39 nM (IC50)


[In Vitro]

CDK9-IN-1 is a potent CDK9 inhibitor that shows high activity against HIV-1 replication[1].

[References]

[1]. Nemeth G, et al. Novel, selective CDK9 inhibitors for the treatment of HIV infection. Curr Med Chem. 2011;18(3):342-358.


[Related Small Molecules]

Abemaciclib(LY2835219) | Ribociclib (LEE011) | Dinaciclib (SCH727965) | THZ1 2HCl | Roscovitine (CYC202) | THZ531 | RO-3306 | Flavopiridol | NVP 2 | BAY-1143572 Racemate | CYC-065 | Cenicriviroc | Ebselen | AZD5438 | Triciribine

Chemical & Physical Properties

[ Molecular Formula ]:
C26H21N5O4S

[ Molecular Weight ]:
499.54100

[ Exact Mass ]:
499.13100

[ PSA ]:
129.74000

[ LogP ]:
5.65950

[ Storage condition ]:
2-8℃

Related Compounds