Rivaroxaban Impurity 3

Names

[ Name ]:
Rivaroxaban Impurity 3

[Synonym ]:
N-[[(5S)-2-Oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide

Biological Activity

[Description]:

Dechloro Rivaroxaban is a highly selective, orally active inhibitor of Factor Xa. Dechloro Rivaroxaban inhibits human free FXa with a Ki of 0.4 nM. Dechloro Rivaroxaban inhibits prothrombinase activity and fibrin-associated FXa activity with IC50s of 2.1 nM and 92 nM, respectively[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Factor Xa

[References]

[1]. Lang D, et al. In vitro metabolism of rivaroxaban, an oral, direct factor Xa inhibitor, in liver microsomes and hepatocytes of rats, dogs, and humans. Drug Metab Dispos. 2009 May;37(5):1046-55.

Chemical & Physical Properties

[ Density]:
1.400±0.06 g/cm3 (20 ºC 760 Torr)

[ Boiling Point ]:
758.0±60.0 °C(Predicted)

[ Melting Point ]:
216-218 °C

[ Molecular Formula ]:
C₁₉H₁₉N₃O₅S

[ Molecular Weight ]:
401.44

Rivaroxaban Impurity 3

Names

Biological Activity

Chemical & Physical Properties

Related Compounds