Lenalidomide-OH

Names

[ Name ]:
Lenalidomide-OH

[Synonym ]:
MFCD31794971

Biological Activity

[Description]:

Lenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BTK degrader SJF620 (HY-133137)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

[Target]

Cereblon

[In Vitro]

Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].

[References]

[1]. Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₁₂N₂O₄

[ Molecular Weight ]:
260.25

Safety Information

[ Hazard Codes ]:
Xi

Lenalidomide-OH

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds