Biotin-PEG11-amine

Names

[ CAS No. ]:
1418022-42-0

[ Name ]:
Biotin-PEG11-amine

Biological Activity

[Description]:

Biotin-PEG11-amine is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₄H₆₆N₄O₁₃S

[ Molecular Weight ]:
770.97

[ Storage condition ]:
-20°C

Biotin-PEG11-amine

Names

Biological Activity

Chemical & Physical Properties

Related Compounds