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IM156

Names

[ CAS No. ]:
1422365-93-2

[ Name ]:
IM156

[Synonym ]:
N-{N-[4-(Trifluoromethoxy)phenyl]carbamimidoyl}-1-pyrrolidinecarboximidamide
1-Pyrrolidinecarboximidamide, N-[imino[[4-(trifluoromethoxy)phenyl]amino]methyl]-

Biological Activity

[Description]:

Lixumistat (IM156) is a novel biguanide mitochondrial protein complex 1 inhibitor of oxidative phosphorylation (OXPHOS) with anti-tumor activity. Lixumistat regulates OXPHOS to attenuate mitochondrial metabolic reprogramming and inhibit lung fibrosis. Lixumistat also suppresses B-cell activation to alleviate systemic lupus erythematosus[1][5].

[Related Catalog]:

Research Areas >> Cancer

[Target]

oxidative phosphorylation (OXPHOS)[1]


[References]

[1]. Willette RN, et al. Modulation of Oxidative Phosphorylation with IM156 Attenuates Mitochondrial Metabolic Reprogramming and Inhibits Pulmonary Fibrosis. J Pharmacol Exp Ther. 2021 Nov;379(3):290-300.  

[2]. Shim JS, Kim EJ, Lee LE, Kim JY, Cho Y, Kim H, Kim J, Jang SH, Son J, Cheong JH, Kim A, Lim BJ, Ha SJ, Song JJ, Kim BS. The oxidative phosphorylation inhibitor IM156 suppresses B-cell activation by regulating mitochondrial membrane potential and contributes to the mitigation of systemic lupus erythematosus. Kidney Int. 2023 Feb;103(2):343-356.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
337.2±52.0 °C at 760 mmHg

[ Molecular Formula ]:
C13H16F3N5O

[ Molecular Weight ]:
315.29

[ Flash Point ]:
157.8±30.7 °C

[ Exact Mass ]:
315.130707

[ LogP ]:
0.96

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.578

Safety Information

[ Hazard Codes ]:
Xn

Related Compounds