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tert-Butyl (6-bromohexyl)carbamate

Names

[ CAS No. ]:
142356-33-0

[ Name ]:
tert-Butyl (6-bromohexyl)carbamate

[Synonym ]:
tert-butyl N-(6-bromohexyl)carbamate
2-Methyl-2-propanyl (6-bromohexyl)carbamate
tert-Butyl (6-bromohexyl)carbamate
Carbamic acid, N-(6-bromohexyl)-, 1,1-dimethylethyl ester

Biological Activity

[Description]:

Boc-NH-C6-Br is a cleavable linker used for antibody-drug conjugates (ADC)[1].

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Jan Anderl, et al. Amatoxin-antibody conjugates. WO2016142049A1.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
340.1±25.0 °C at 760 mmHg

[ Molecular Formula ]:
C11H22BrNO2

[ Molecular Weight ]:
280.202

[ Flash Point ]:
159.5±23.2 °C

[ Exact Mass ]:
279.083374

[ PSA ]:
38.33000

[ LogP ]:
3.63

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.473

[ Storage condition ]:
2-8°C

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R41

[ Safety Phrases ]:
26-39

[ RIDADR ]:
UN 3082 9/PG 3

[ WGK Germany ]:
3

[ HS Code ]:
2924199090

Synthetic Route

Precursor & DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Methoxy poly (ethylene glycol)-block-poly (glutamic acid)-graft-6-(2-nitroimidazole) hexyl amine nanoparticles for potential hypoxia-responsive delivery of doxorubicin.

J. Biomater. Sci. Polym. Ed. 27 , 40-54, (2015)

Tumor microenvironment-responsive nano drug delivery vehicles are gaining mounting attention in the field of biomedical sciences. The hypoxic response of the tumorous cells due to very low partial pre...

T.H. Keller, R. Haener

Helv. Chim. Acta 76 , 884, (1993)

D. Damour et al.

Bioorg. Med. Chem. Lett. 6 , 1667 , (1996)


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Related Compounds