B-Raf IN 10

B-Raf IN 10 (Compound C09) is a BRAF inhibitor with an IC50 between 50 and 100 nM. B-Raf IN 10 shows antitumor activity[1].

Research Areas >> Cancer

Signaling Pathways >> MAPK/ERK Pathway >> Raf

BRAF-V600E:< 50 nM (IC50)

Braf:50-100 nM (IC50)

B-Raf IN 10 (Compound C09) (1 μM) shows more than 89% inhibition against BRAF and BRAF V600E[1]. B-Raf IN 10 shows an IC50 between 50 and 100 nM against BRAF, less than 50 nM against BRAF V600E[1]. B-Raf IN 10 (72 h) inhibits A375 and SK-MEL-28 cells growth but not CHL-1 and SK-MEL-31 cells[1]. Cell Viability Assay[1] Cell Line: A375, SK-MEL-28, SK-MEL-31 and CHL-1 Concentration: Incubation Time: 72 h Result: Showed inhibition with IC50s less than 500 nM against A375 and SK-MEL-28 cells, and showed no inhibition against CHL-1 and SK-MEL-31.

[1]. Yong-Liang Zhu, et al. Certain Chemical Entities, Compositions, and Methods. Patent US20130053384 A1.