5’-O-DMTr-2’,2’-difluoro-dC(Bz)-3’-CED-phosphoramidite

Names

[ Name ]:
5’-O-DMTr-2’,2’-difluoro-dC(Bz)-3’-CED-phosphoramidite

Biological Activity

[Description]:

5’-O-DMTr-2’,2’-difluoro-dC(Bz)-3’-CED-phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₆H₅₀F₂N₅O₈P

[ Molecular Weight ]:
869.89

[ Storage condition ]:
2-8℃