M35

Names

[ Name ]:
M35

[Synonym ]:
GWTLNSAGYLLGPPPGFSPFR-CONH2
L-Argininamide,glycyl-L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-L-leucylglycyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl
M 35
Galanin-(1-13)-bradykinin-(2-9)-amide

Biological Activity

[Description]:

Galanin Receptor Ligand M35 is a high-affinity galanin receptor ligand acting as a galanin receptor antagonist in the rat spinal cord, rat hippocampus and isolated mouse pancreatic islets. Galanin Receptor Ligand M35 exerts a Ki values of 0.11 and 2.0 nM for human GalR1 and GalR2, respectively[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor

[Target]

Ki: 0.11 nM (GalR1), 2.0 nM (GalR2)[2]

[References]

[1]. Kask K, et al. Binding and agonist/antagonist actions of M35, galanin(1-13)-bradykinin(2-9)amide chimeric peptide, in Rin m 5F insulinoma cells. Regul Pept. 1995 Nov 10;59(3):341-8.

[2]. Webling KE, et al. Galanin receptors and ligands. Front Endocrinol (Lausanne). 2012 Dec 7;3:146.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀₇H₁₅₃N₂₇O₂₆

[ Molecular Weight ]:
2233.60

[ Exact Mass ]:
2232.15000

[ PSA ]:
817.65000

[ LogP ]:
2.16320

Safety Information

[ Safety Phrases ]:
22-24/25