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Triptoquinone B

Names

[ CAS No. ]:
142937-50-6

[ Name ]:
Triptoquinone B

[Synonym ]:
1,4,7(4bH)-Phenanthrenetrione, 5,6,8,8a,9,10-hexahydro-8-(hydroxymethyl)-4b,8-dimethyl-2-(1-methylethyl)-, (4bS,8S,8aR)-
19-Hydroxyabieta-8,12-diene-3,11,14-trione
Triptoquinone B

Biological Activity

[Description]:

Triptoquinone B ((+)-Triptoquinone B), a sesquiterpene alkaloid, is an interleukin-1 inhibitor. Triptoquinone B shows potent inhibitory activities against interleukin 1α and β releases for human peripheral mononuclear cells[1][2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Interleukin Related
Research Areas >> Inflammation/Immunology

[Target]

IL-1


[References]

[1]. Takaishi Y, et, al. Triptoquinone A and B novel interleukin-1 inhibitors from Tripterygium wilfordii var Regeli. Tetrahedron Letters. 1992 Nov; 33(47): 7177-7180.

[2]. Wang XD, et, al. Terpene alkaloids from Tripterygium wilfordii. J Asian Nat Prod Res. 2005 Oct;7(5):755-9.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
475.4±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H26O4

[ Molecular Weight ]:
330.418

[ Flash Point ]:
255.4±25.2 °C

[ Exact Mass ]:
330.183105

[ PSA ]:
71.44000

[ LogP ]:
2.77

[ Vapour Pressure ]:
0.0±2.7 mmHg at 25°C

[ Index of Refraction ]:
1.558

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds