Sodium Oleate

Names

[ CAS No. ]:
143-19-1

[ Name ]:
Sodium Oleate

[Synonym ]:
Sodium oleate
sodium cis-9-octadecanoate
eunatrol
Lunac SO 90L
olateflakes
EINECS 205-591-0
Pionin D 951P
Approx
Oleic acid,sodium salt
Nonsoul ON 1
Nonsoul ON-A
cis-9-Octadecenoic acid sodium salt,Oleic acid sodium salt
sodiunm oleate
osteum
SodiumOleatePure
MFCD00004438
cis-Oleate sodium salt
Oleic Acid Sodium Salt

Biological Activity

[Description]:

Sodium oleate (Oleic acid sodium) is an abundant monounsaturated fatty acid sodium[1]. Sodium oleate is a Na+/K+ ATPase activator[2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Research Areas >> Metabolic Disease

[Target]

Na+/K+ ATPase[2]

[In Vitro]

Oleic acid is the most common monounsaturated fatty acids (FA) in human adipocytes and other tissues. Oleic acid prompts cell proliferation and migration in high metastatic cancer cells via enhancing β-oxidation mediated by AMPK activation. Oleic acid inhibits cancer cell growth and survival in low metastatic carcinoma cells, such as gastric carcinoma SGC7901 and breast carcinoma MCF-7 cell lines[1].

[References]

[1]. Li S, et al. High metastaticgastric and breast cancer cells consume oleic acid in an AMPK dependent manner. PLoS One. 2014 May 13;9(5):e97330.

[2]. Jack-Hays MG, et al. Activation of Na+/K(+)-ATPase by fatty acids, acylglycerols, and related amphiphiles: structure-activity relationship. Biochim Biophys Acta. 1996 Feb 21;1279(1):43-8.

Chemical & Physical Properties

[ Density]:
0.9 g/cm3

[ Boiling Point ]:
359.999ºC at 760 mmHg

[ Melting Point ]:
232-235 °C(lit.)

[ Molecular Formula ]:
C₁₈H₃₃NaO₂

[ Molecular Weight ]:
304.443

[ Flash Point ]:
270.099ºC

[ Exact Mass ]:
304.237823

[ PSA ]:
40.13000

[ LogP ]:
4.77380

[ Storage condition ]:
−20°C

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RK1200000

CHEMICAL NAME :: Oleic acid, sodium salt

CAS REGISTRY NUMBER :: 143-19-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C18-H33-O2.Na

MOLECULAR WEIGHT :: 304.50

WISWESSER LINE NOTATION :: QV8U9 &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 152 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,327,1970

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 24,221,1925 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0760 No. of Facilities: 11635 (estimated) No. of Industries: 91 No. of Occupations: 92 No. of Employees: 122970 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0760 No. of Facilities: 8020 (estimated) No. of Industries: 88 No. of Occupations: 92 No. of Employees: 162242 (estimated) No. of Female Employees: 33454 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ RTECS ]:
RK1200000

[ HS Code ]:
2916150000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2916150000

[ Summary ]:
2916150000 oleic, linoleic or linolenic acids, their salts and esters。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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