CCG-203586

Names

[ Name ]:
CCG-203586

Biological Activity

[Description]:

A potent, CNS-active Glucosylceramide synthase (GCS) inhibitor with IC50 of 27 nM; inhibits GlcCer production in whole wild-type MDCKII cells with IC50 of 15.3 nM, has little to no apparent recognition by MDR1; significantly and dose-dependently decreases brain glucosylceramide content after intraperitoneal administration in mice.

[References]

References 1. Larsen SD, et al. J Lipid Res. 2012 Feb;53(2):282-91. 2. Arthur JR, et al. Neurochem Res. 2013 Apr;38(4):866-75. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₃₂N₂O₄

[ Molecular Weight ]:
436.552

Related Compounds

ccg-9810
4-[2-[(Z)-(3-bromo-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]hydrazinyl]-N-(2-methylphenyl)-4-oxobutanamide
3-N,3-N,7-N,7-N,11-N,11-N,3,7,11-nonamethyl-1,2,5,6,9,10-hexathiacyclododecane-3,7,11-tricarboxamide
CCG-273463
CCG-271423
methyl 4-(4-hydroxy-3-nitrophenyl)-2-methyl-5-oxo-7-phenyl-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylate
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide
N-[3-(Aminooxy)propyl]-N-butyl-1-butanamine