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GSK-LSD1 2HCL

Names

[ CAS No. ]:
1431368-48-7

[ Name ]:
GSK-LSD1 2HCL

[Synonym ]:
N-[(1R,2S)-2-Phenylcyclopropyl]-4-piperidinamine
4-Piperidinamine, N-[(1R,2S)-2-phenylcyclopropyl]-
GSK-LSD1 2HCL
GSK-LSD1 (hydrochloride)
LSD1 inhibitor

Biological Activity

[Description]:

GSK-LSD1 is a LSD1 inhibitor. GSK-LSD1 reduces food intake and body weight, and improves insulin sensitivity and glycemic control in mouse models of obesity. GSK-LSD1 also ameliorates NAFLD. GSK-LSD1 inhibits SARS-CoV-2-triggered cytokine release in COVID-19 PBMCs. GSK-LSD1 also inhibits cancer growth and metastasis[1][2][3].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Infection
Signaling Pathways >> Epigenetics >> Histone Demethylase
Research Areas >> Metabolic Disease

[References]

[1]. Ramms B, et al. Systemic LSD1 Inhibition Prevents Aberrant Remodeling of Metabolism in Obesity. Diabetes. 2022 Dec 1;71(12):2513-2529.  

[2]. Hong KS, et al. GSK-LSD1, an LSD1 inhibitor, quashes SARS-CoV-2-triggered cytokine release syndrome in-vitro. Signal Transduct Target Ther. 2020 Nov 17;5(1):267.  

[3]. Alsaqer SF, et al. Inhibition of LSD1 epigenetically attenuates oral cancer growth and metastasis. Oncotarget. 2017 Jul 27;8(43):73372-73386.  

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
347.4±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C14H20N2

[ Molecular Weight ]:
216.322

[ Flash Point ]:
206.0±19.7 °C

[ Exact Mass ]:
216.162643

[ LogP ]:
1.63

[ Appearance of Characters ]:
white to beige

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.580

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
H2O: soluble20mg/mL, clear

Related Compounds