SIRT-IN-2

SIRT-IN-2 is a potent inhibitor of SIRT1/2/3, with IC50s of 4, 4, 7 μM, respectively.

Research Areas >> Others

SIRT1:4 nM (IC50)

SIRT2:1 nM (IC50)

SIRT3:7 nM (IC50)

SIRT-IN-2 (compound 31) is one of the most potent truncated pan SIRT1/ 2/3 inhibitor, the IC50 values are 4, 4, 7 μM, respectively. SIRT-IN-2 (SIRT1/2/3 pan inhibitor) binds identically in the catalytic active site (RMS=0.29 Å), occupying the nicotinamide C-pocket and acetyl lysine substrate channel[1].

[1]. Disch JS, et al. Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem. 2013 May 9;56(9):3666-79.

Selisistat (EX 527) | Nicotinamide | SRT1720 HCl | Sirtinol | 3-TYP | SRT 2104 | Fisetin | OSS_128167 | Thiomyristoyl | Cambinol | Tenovin-1 | CAY10602 | AK-7 | Inauhzin | Tenovin 6 Hydrochloride