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ACT-373898

Names

[ CAS No. ]:
1433875-14-9

[ Name ]:
ACT-373898

Biological Activity

[Description]:

ACT-373898 is an inactive carboxylic acid metabolite of Macitentan. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin receptor) antagonist[1].

[Related Catalog]:

Research Areas >> Endocrinology
Signaling Pathways >> Others >> Others

[In Vitro]

The elimination half-life (t1/2) is approximately 16 h for Macitentan, and ACT-373898 has a similar pharmacokinetic (PK) profile to Macitentan[1].

[References]

[1]. Shirin Bruderer, et al. Effect of cyclosporine and rifampin on the pharmacokinetics of macitentan, a tissue-targeting dual endothelin receptor antagonist. AAPS J. 2012 Mar;14(1):68-78.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds