WKYMVM-NH2 TFA
Names
[ CAS No. ]:
1435781-74-0
[ Name ]:
WKYMVM-NH2 TFA
Biological Activity
[Description]:
WKYMVM-NH2 TFA is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase[1][2][3].
[Related Catalog]:
[In Vitro]
WKYMVM-NH2 TFA (10-1000 nM; 24 hours) induces Caco-2 cells proliferation[3]. Cell Proliferation Assay[3] Cell Line: Caco-2 cells (the intestinal epithelial cells) Concentration: 0 nM, 10 nM, 100 nM, 1000 nM Incubation Time: 24 hours Result: Induced cell proliferation.
[In Vivo]
WKYMVM-NH2 TFA (8 mg/kg; six times; for 5 days) ameliorates DSS-induced ulcerative colitis[3]. WKYMVM-NH2 TFA affects cytokine (IL-17, IFN-γ, IL-6, IL-1β and TNF-α) profiles in the DSS colitis model[3]. Animal Model: Six-week-old C57BL/6 mice, DSS model[3] Dosage: 8 mg/kg Administration: Subcutaneously injected, six subcutaneous administrations at 12-h intervals, for 5 days Result: Attenuated the DSS-induced increase in the bleeding score and the stool score.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C43H62F3N9O9S2
[ Molecular Weight ]:
970.13