3'-O-(t-Butyldimethylsilyl)-2'-deoxy-2'-fluorouridine

Names

[ Name ]:
3'-O-(t-Butyldimethylsilyl)-2'-deoxy-2'-fluorouridine

[Synonym ]:
Uridine, 2'-deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluoro-
2'-Deoxy-3'-O-[dimethyl(2-methyl-2-propanyl)silyl]-2'-fluorouridine

Biological Activity

[Description]:

3'-O-(t-Butyldimethylsilyl)-2'-deoxy-2'-fluorouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Molecular Formula ]:
C₁₅H₂₅FN₂O₅Si

[ Molecular Weight ]:
360.45

[ Exact Mass ]:
360.151672

[ LogP ]:
1.78

[ Index of Refraction ]:
1.519

3'-O-(t-Butyldimethylsilyl)-2'-deoxy-2'-fluorouridine

Names

Biological Activity

Chemical & Physical Properties

Related Compounds