Hematoporphyrin

Names

[ Name ]:
Hematoporphyrin

[Synonym ]:
EINECS 238-450-7
Photodyn
HematoporphyrineBase
MFCD00005077
3,3'-[7,12-Bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-2,18-porphyrindiyl]dipropanoic acid
1,3,5,8-Tetramethyl-2,4-bis(a-hydroxyethyl)porphine-6,7-dipropionic Acid
21H,23H-Porphine-2,18-dipropanoic acid, 8,13-bis(1-hydroxyethyl)-3,7,12,17-tetramethyl-
3,3'-[7,12-Bis(1-hydroxyethyl)-3,8,13,17-tetramethylporphyrin-2,18-diyl]dipropanoic acid
Hematoporphyrin
Sensibion

Biological Activity

[Description]:

Hematoporphyrin (Hematoporphyrin IX) is a substrate for affinity chromatography of heme-binding proteins.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Others

[In Vitro]

Hematoporphyrin is used for affinity chromatography of heme-binding proteins. Hematoporphyrin is used in the characterization and synthesis of hematoporphyrin- and hematin-agarose [1].

[References]

[1]. Olsen, K.W., Affinity chromatography of heme-binding proteins: synthesis and characterization of hematin- and hematoporphyrin-agarose. Methods Enzymol, 1986. 123: p. 324-31.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
1179.7±65.0 °C at 760 mmHg

[ Melting Point ]:
172.5°C

[ Molecular Formula ]:
C₃₄H₃₈N₄O₆

[ Molecular Weight ]:
598.689

[ Flash Point ]:
667.3±34.3 °C

[ Exact Mass ]:
598.279114

[ PSA ]:
171.36000

[ LogP ]:
5.95

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.642

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TS5500000

CHEMICAL NAME :: 2,18-Porphinedipropionic acid, 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-

CAS REGISTRY NUMBER :: 14459-29-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C34-H38-N4-O6

MOLECULAR WEIGHT :: 598.76

WISWESSER LINE NOTATION :: T D5 I5 N5-16-5 A D- I- N- AM D-N I-M N-NJ EYQ F J K2VQ O2VQ TYQ U

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 307 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - other changes

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 1 mg/L

REFERENCE :: TUMOAB Tumori. (Casa Editrice Ambrosiana, Via G. Frua 6, 20146 Milan, Italy) V.1- 1911- Volume(issue)/page/year: 67,183,1981

Safety Information

[ Safety Phrases ]:
22-24/25

[ WGK Germany ]:
3

[ RTECS ]:
TS5500000