Amino-PEG5-Boc

Names

[ Name ]:
Amino-PEG5-Boc

[Synonym ]:
2-Methyl-2-propanyl 1-amino-3,6,9,12,15-pentaoxaoctadecan-18-oate
3,6,9,12,15-Pentaoxaoctadecan-18-oic acid, 1-amino-, 1,1-dimethylethyl ester
MFCD25424125
Amino-PEG6-t-butyl ester
Amino-PEG5-t-butyl ester

Biological Activity

[Description]:

Amino-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
439.1±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₃₅NO₇

[ Molecular Weight ]:
365.462

[ Flash Point ]:
114.1±23.7 °C

[ Exact Mass ]:
365.241364

[ LogP ]:
-0.59

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.457

Safety Information

[ Hazard Codes ]:
Xn

Amino-PEG5-Boc

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds