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GBT-440

Names

[ CAS No. ]:
1446321-46-5

[ Name ]:
GBT-440

[Synonym ]:
Benzaldehyde, 2-hydroxy-6-[[2-[1-(1-methylethyl)-1H-pyrazol-5-yl]-3-pyridinyl]methoxy]-
2-Hydroxy-6-{[2-(1-isopropyl-1H-pyrazol-5-yl)-3-pyridinyl]methoxy}benzaldehyde
voxelotor
GBT-440
GBT 440

Biological Activity

[Description]:

GBT 440 (Voxelotor) is an orally bioavailable modulator of sickle cell hemoglobin.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Cardiovascular Disease

[References]

[1]. Metcalf B, et al. Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin. ACS Med Chem Lett. 2017 Jan 23;8(3):321-326.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
539.2±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H19N3O3

[ Molecular Weight ]:
337.372

[ Flash Point ]:
279.9±30.1 °C

[ Exact Mass ]:
337.142639

[ LogP ]:
2.85

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.617

[ Storage condition ]:
-20℃

Related Compounds