MET kinase-IN-3

Names

[ CAS No. ]:
1446324-02-2

[ Name ]:
MET kinase-IN-3

Biological Activity

[Description]:

MET kinase-IN-3 (compound 8) is an orally active and potent MET inhibitor, with an IC50 of 9.8 nM. MET kinase-IN-3 shows good and broad-spectrum antiproliferative activity against cancer cell lines[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Met/HGFR

[Target]

MET:9.8 nM (IC50)

VEGFR2:68 nM (IC50)


[References]

[1]. Wang MS, et al. Synthesis and biological evaluation of new MET inhibitors with 1,6-naphthyridinone scaffold. Eur J Med Chem. 2020 Jan 1;185:111803.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H16ClF2N5O2

[ Molecular Weight ]:
491.88

Related Compounds