c-Met-IN-11

Names

[ CAS No. ]:
1446324-05-5

[ Name ]:
c-Met-IN-11

Biological Activity

[Description]:

c-Met-IN-11 (compound 3) is a potent c-MET and VEGFR-2 inhibitor, with IC50 values of 41.4 and 71.1 nM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Met/HGFR

[Target]

c-Met:41.4 nM (IC50)

VEGFR-2:71.1 nM (IC50)

[References]

[1]. Xu H, et al. Discovery of N-substituted-3-phenyl-1,6-naphthyridinone derivatives bearing quinoline moiety as selective type II c-Met kinase inhibitors against VEGFR-2. Bioorg Med Chem. 2020 Jun 15;28(12):115555.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₀H₂₀F₂N₄O₃

[ Molecular Weight ]:
522.50

Related Compounds