AGI-12026

Names

[ Name ]:
AGI-12026

Biological Activity

[Description]:

AGI-12026 is brain-penetrant dual inhibitor of mutant IDH1 and 2. AGI-12026 shows partial inhibition of the IDH1-R132H homodimer as allosteric modulators. AGI-12026 has the potential for research of glioma[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Isocitrate Dehydrogenase (IDH)

Research Areas >> Neurological Disease

[References]

[1]. Konteatis Z, et al. Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma. ACS Med Chem Lett. 2020;11(2):101-107.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₅F₆N₇

[ Molecular Weight ]:
443.35

AGI-12026

Names

Biological Activity

Chemical & Physical Properties

Related Compounds