Phosphatidylserines (bovine)

Names

[ Name ]:
Phosphatidylserines (bovine)

[Synonym ]:
Octadecanoic acid, (1R)-1-[[[[(2S)-2-amino-2-carboxyethoxy]hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester
1,2-distearoyl-sn-glycero-3-phosphoserine
O-{[(2R)-2,3-Bis(stearoyloxy)propoxy](hydroxy)phosphoryl}-L-serine
MFCD00135635
Phosphatidylserine

Biological Activity

[Description]:

Phosphatidylserine is a conserved anti-inflammatory and immunosuppressive signal that is highly dysregulated in the tumor microenvironment and autoimmune diseases. During apoptosis and cellular stress，the related disrupting enzymes Xkr8 and TMEM16 mediate Phosphatidylserine externalization. Phosphatidylserine externalization produces a "eat me" signal that initiates endocytosis and helps clear the body of apoptotic cells. When pathogens use Phosphatidylserine and apoptotic mimicry to evade host immune responses，targeting Phosphatidylserine strategies can stimulate immune activity[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Birge RB, Boeltz S, Kumar S, Carlson J, Wanderley J, Calianese D, Barcinski M, Brekken RA, Huang X, Hutchins JT, Freimark B, Empig C, Mercer J, Schroit AJ, Schett G, Herrmann M. Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer. Cell Death Differ. 2016 Jun;23(6):962-78.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
816.3±75.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄₂H₈₂NO₁₀P

[ Molecular Weight ]:
792.075

[ Flash Point ]:
447.5±37.1 °C

[ Exact Mass ]:
791.567627

[ LogP ]:
16.13

[ Vapour Pressure ]:
0.0±6.3 mmHg at 25°C

[ Index of Refraction ]:
1.481

Phosphatidylserines (bovine)

Names

Biological Activity

Chemical & Physical Properties

Related Compounds