cyclophostin

Names

[ Name ]:
cyclophostin

[Synonym ]:
Cyclophostin
Rac-Cyclophostin
1H,6H-Furo(3,4-e)(1,3,2)dioxaphosphepin-6-one,8,8a-dihydro-3-methoxy-5-methyl-,3-oxide,(3R-cis)

Biological Activity

[Description]:

Cyclophostin is an acetylcholinesterase (AChE) inhibitor with IC50 values of 45, 0.76 and 1.3 nM for humans and two different insects, respectively[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> AChE

[References]

[1]. Spilling CD. The Chemistry and Biology of Cyclophostin, the Cyclipostins and Related Compounds. Molecules. 2019 Jul 16;24(14):2579.

Chemical & Physical Properties

[ Density]:
1.41g/cm3

[ Boiling Point ]:
338.1ºC at 760mmHg

[ Molecular Formula ]:
C₈H₁₁O₆P

[ Molecular Weight ]:
234.14300

[ Flash Point ]:
172ºC

[ Exact Mass ]:
234.02900

[ PSA ]:
80.87000

[ LogP ]:
1.23470

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.495