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VHL Ligand 3

Names

[ CAS No. ]:
1448189-98-7

[ Name ]:
VHL Ligand 3

[Synonym ]:
L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
3-Methyl-N-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide

Biological Activity

[Description]:

A VHL ligand for PROTAC.

[References]

References 1. Wurz RP, et al. J Med Chem. 2017 Apr 17. doi: 10.1021/acs.jmedchem.6b01781. 2. Zengerle M, et al. ACS Chem Biol. 2015 Aug 21;10(8):1770-7. View Related Products by Target E3 Ligase Ligand

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
755.7±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C27H38N4O5S

[ Molecular Weight ]:
530.679

[ Flash Point ]:
410.9±32.9 °C

[ Exact Mass ]:
530.256287

[ LogP ]:
2.63

[ Vapour Pressure ]:
0.0±2.7 mmHg at 25°C

[ Index of Refraction ]:
1.572

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds