UM729

Names

[ Name ]:
UM729

[Synonym ]:
9H-Pyrimido[4,5-b]indole-7-carboxylic acid, 4-[[3-(1-piperidinyl)propyl]amino]-, methyl ester
Methyl 4-{[3-(1-piperidinyl)propyl]amino}-1H-pyrimido[4,5-b]indole-7-carboxylate
UM729

Biological Activity

[Description]:

UM729 is a new pyrimidoindole, which has an additive effect with AhR antagonists in preventing differentiation in most AML specimens; collaborates with Ahr suppressors in preventing AML cell differentiation.IC50 value:Target: SR1 and UM729 can be implemented as a standardized supplement in culture media and will pave the way for studies of self-renewal mechanisms and for the identification of new antileukemic drugs through cell-based assays for primary human AML cells.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Fungal

Research Areas >> Inflammation/Immunology

[References]

[1]. Mojumder DK, et al. Evaluating retinal toxicity of intravitreal caspofungin in the mouse eye. Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5796-803.

[2]. Flattery, Amy M. et al. Efficacy of caspofungin in a juvenile mouse model of central nervous system candidiasis. Antimicrobial Agents and Chemotherapy (2011), 55(7), 3491-3497.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
611.1±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₅N₅O₂

[ Molecular Weight ]:
367.44

[ Flash Point ]:
323.4±31.5 °C

[ Exact Mass ]:
367.200836

[ LogP ]:
4.10

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.677