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2-Amino-6-chloropurine-9-beta-D-(2’-deoxy-2’-fluoro)-arabinoriboside

Names

[ CAS No. ]:
144924-88-9

[ Name ]:
2-Amino-6-chloropurine-9-beta-D-(2’-deoxy-2’-fluoro)-arabinoriboside

[Synonym ]:
2’-deoxy-2’-β-fluoro-6-chloroguanosine
2-amino-6-chloro-9-(2-fluoro-β-D-arabinosyl)purine
(2R,3R,4S,5R)-5-(2-Amino-6-chloro-purin-9-yl)-4-fluoro-2-hydroxymethyl-tetrahydro-furan-3-ol

Biological Activity

[Description]:

2-Amino-6-chloropurine-9-beta-D-(2’-deoxy-2’-fluoro)-arabinoriboside is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Molecular Formula ]:
C10H11ClFN5O3

[ Molecular Weight ]:
303.68

[ Exact Mass ]:
303.05300

[ PSA ]:
119.31000

[ LogP ]:
0.23180

Related Compounds