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Hydrolyzed Fumonisin B1

Names

[ CAS No. ]:
145040-09-1

[ Name ]:
Hydrolyzed Fumonisin B1

[Synonym ]:
Aminopentol
HFB1

Biological Activity

[Description]:

Hydrolyzed Fumonisin B1 (Aminopentol) is the backbone and main hydrolysis product of the mycotoxin fumonisin B1 (FB1), can weakly inhibit ceramide synthase[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Neurological Disease

[References]

[1]. Collins TF, et al. Effects of aminopentol on in utero development in rats. Food Chem Toxicol. 2006 Feb;44(2):161-9.

[2]. Humpf HU, et al. Acylation of naturally occurring and synthetic 1-deoxysphinganines by ceramide synthase. Formation of N-palmitoyl-aminopentol produces a toxic metabolite of hydrolyzed fumonisin, AP1, and a new category of ceramide synthase inhibitor. J Biol Chem. 1998 Jul 24;273(30):19060-4.

[3]. Schmelz EM, et al. Induction of apoptosis by fumonisin B1 in HT29 cells is mediated by the accumulation of endogenous free sphingoid bases. Toxicol Appl Pharmacol. 1998 Feb;148(2):252-60.

Chemical & Physical Properties

[ Density]:
1.051±0.06 g/cm3(Predicted)

[ Boiling Point ]:
593.8±50.0 °C(Predicted)

[ Molecular Formula ]:
C22H47NO5

[ Molecular Weight ]:
405.61200

[ Exact Mass ]:
405.34500

[ PSA ]:
127.17000

[ LogP ]:
3.03150

[ Vapour Pressure ]:
1.42E-16mmHg at 25°C

[ Storage condition ]:
-20°C

Related Compounds