Comins' Reagent

Names

[ Name ]:
Comins' Reagent

[Synonym ]:
2-[N,N-Bis(trifluoromethanesulfonyl)amino]-5-chloropyridine
N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-(trifluoromethylsulfonyl)methanesulfonamide
N-(5-Chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulfonyl]methanesulfonamide
2-(N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine
N-(5-Chloro-2-pyridyl)bis(trifluoromethanesulf
N-(5-Chloro-2-pyridyl)triflimide
MFCD00191833
N-(5-Chloro-2-pyridyl)bis(trifluoromethanesulfonyl)imide
N-(5-Chloro-2-pyridyl)bis(trifluoromethanesulfonimide)
Comins Triflating
2-[N,N-Bis(Trifluoromethylsulphonyl)amino]-5-chloropyridine
Comins' Reagent
Methanesulfonamide, N-(5-chloro-2-pyridinyl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulfonyl]-
N-(5-Chloro-2-pyridinyl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulfonyl]methanesulfonamide

Chemical & Physical Properties

[ Density]:
1.9±0.1 g/cm3

[ Boiling Point ]:
358.3±52.0 °C at 760 mmHg

[ Melting Point ]:
45-47 °C(lit.)

[ Molecular Formula ]:
C₇H₃ClF₆N₂O₄S₂

[ Molecular Weight ]:
392.683

[ Flash Point ]:
170.5±30.7 °C

[ Exact Mass ]:
391.912689

[ PSA ]:
101.17000

[ LogP ]:
2.68

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.499

[ Storage condition ]:
Keep Cold

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2935009090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Articles

Total synthesis of the antimitotic marine macrolide (-)-leiodermatolide.

Angew. Chem. Int. Ed. Engl. 53(10) , 2692-5, (2014)

Leiodermatolide is an antimitotic macrolide isolated from the marine sponge Leiodermatium sp. whose potentially novel tubulin-targeting mechanism of action makes it an exciting lead for anticancer dru...

Tetrahedron Lett. 33 , 6299, (1992)

Tetrahedron Lett. 44 , 9185, (2003)