H-Met-Ser-OH

Names

[ Name ]:
H-Met-Ser-OH

[Synonym ]:
L-methionine-L-serine
L-Met-L-Ser-OH
MET-SER
Met-Ser-OH
L-METHIONYL-L-SERINE
L-MET-SER
N-L-Methionyl-L-serine

Biological Activity

[Description]:

Methionylserine (H-MET-SER-OH) is a methionine- and serine-containing dipeptide. Methionylserine binds to and translocation via intestinal di/tri-peptide transporter 1 (hPEPT1) with a Km value of 0.2 mM. Methionylserine inhibits ACE enzyme activity. Methionylserine can be used in the research of hypension[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)

[Target]

hPEPT1[1], ACE[2].

[References]

[1]. Diana Højmark Omkvist, et al. Affinity and translocation relationships via hPEPT1 of H-X aa-Ser-OH dipeptides: evaluation of H-Phe-Ser-OH as a pro-moiety for ibuprofen and benzoic acid prodrugs. Eur J Pharm Biopharm. 2011 Feb;77(2):327-31.

[2]. Pan Wuguang, et al. Application of sulfur dipeptide for preparing antihypertensive drug or health care product. Patent WO2019006954.

Chemical & Physical Properties

[ Molecular Formula ]:
C₈H₁₆N₂O₄S

[ Molecular Weight ]:
236.28900

[ Exact Mass ]:
236.08300

[ PSA ]:
137.95000

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2930909090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Neuraminidase inhibitors for influenza.

Biochem. Biophys. Res. Commun. 337 , 1125-32, (2005)