VU 0467485
Names
[ CAS No. ]:
1451994-10-7
[ Name ]:
VU 0467485
[Synonym ]:
5-Amino-N-(3-fluoro-4-methoxybenzyl)-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide
Thieno[2,3-c]pyridazine-6-carboxamide, 5-amino-N-[(3-fluoro-4-methoxyphenyl)methyl]-3,4-dimethyl-
Biological Activity
[Description]:
VU0467485 (VU-0467485, AZ13713945) is potent, selective, and orally bioavailable muscarinic acetylcholine receptor 4 (M4) positive allosteric modulator with EC50 of 78.8 nM (hM4); possesses robust in vitro M4 PAM potency across species and in vivo efficacy in preclinical models of schizophrenia.
[References]
References 1. Wood MR, et al. ACS Med Chem Lett. 2016 Dec 16;8(2):233-238. 2. Melancon BJ, et al. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2296-2301. 3. Deng X, et al. ChemMedChem. 2018 Dec 27. doi: 10.1002/cmdc.201800710. View Related Products by Target mAChR
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Molecular Formula ]:
C17H17FN4O2S
[ Molecular Weight ]:
360.406
[ Exact Mass ]:
360.105621
[ LogP ]:
3.11
[ Index of Refraction ]:
1.660