Protopanaxatriol

Names

[ Name ]:
Protopanaxatriol

[Synonym ]:
20(R)-Protopanaxtriol
Protopanaxatriol
(20S)-protopanaxatriol
20(R)-Protopanaxtriol(PPT)
Dammar-24-ene-3,6,12,20-tetrol, (3β,6α,12β,20R)-
(3β,6α,12β,20R)-Dammar-24-ene-3,6,12,20-tetrol

Biological Activity

[Description]:

20(R)-Protopanaxatriol is a natural aglycone of ginsenosides Re, Rf, Rg1, Rg2 and Rh.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Others

Natural Products >> Terpenoids and Glycosides

[In Vitro]

20(R)-Protopanaxatriol is a natural aglycone of ginsenosides Re, Rf, Rg1, Rg2 and Rh[1].

[References]

[1]. Bai L, et al. Therapeutic Potential of Ginsenosides as an Adjuvant Treatment for Diabetes. Front Pharmacol. 2018 May 1;9:423.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
590.0±50.0 °C at 760 mmHg

[ Melting Point ]:
261-263 °C

[ Molecular Formula ]:
C₃₀H₅₂O₄

[ Molecular Weight ]:
476.732

[ Flash Point ]:
240.1±24.7 °C

[ Exact Mass ]:
476.386566

[ PSA ]:
80.92000

[ LogP ]:
5.89

[ Vapour Pressure ]:
0.0±3.8 mmHg at 25°C

[ Index of Refraction ]:
1.541

[ Storage condition ]:
2-8°C

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

An integrated high resolution mass spectrometric data acquisition method for rapid screening of saponins in Panax notoginseng (Sanqi).

J. Pharm. Biomed. Anal. 109 , 184-91, (2015)

The aim of this study was to develop a convenient method without pretreatments for nontarget discovery of interested compounds. The segment and exposure strategy, coupled with two mass spectrometer da...

Adulteration and cultivation region identification of American ginseng using HPLC coupled with multivariate analysis.

J. Pharm. Biomed. Anal. 99 , 8-15, (2014)

American ginseng (Panax quinquefolius) is originally grown in North America. Due to price difference and supply shortage, American ginseng recently has been cultivated in northern China. Further, in t...

Cytochrome P450 CYP716A53v2 catalyzes the formation of protopanaxatriol from protopanaxadiol during ginsenoside biosynthesis in Panax ginseng.

Plant Cell Physiol. 53 , 1535-1545, (2012)

Ginseng (Panax ginseng C.A. Meyer) is one of the most popular medicinal herbs, and the root of this plant contains pharmacologically active components, called ginsenosides. Ginsenosides, a class of te...