BI 186908

Names

[ Name ]:
BI 186908

Biological Activity

[Description]:

A potent and selective MCH-R1 antagonist with IC50 of 22 nM, Ki of 14 nM; significantly reduces body weight comparable to sibutramine in a 4 week diet-induced obesity model in rats, possesses favorable DMPK and CMC properties.

[References]

References 1. Oost T, et al. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3275-80. View Related Products by Target Melanin-concentrating Hormone Receptor (MCHR)

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₆N₄O₄

[ Molecular Weight ]:
422.485

Related Compounds

BI Compound D
bi(7-deoxyaklavinon-7-yl)
BI 1015550
BI-0474
BI-685509
BI 135585
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
7-Chloro-2-(4-methoxyphenyl)-4-quinolinecarbonyl chloride
methyl 3-[(1R)-1-amino-2-hydroxyethyl]-4-(dimethylamino)benzoate
N-(2-chloro-4-methoxyphenyl)-2-cyano-3-(furan-2-yl)prop-2-enamide
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde